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Friday, 17 July 2015

Cognitive Symptoms in Type 1 Diabetes Patients.

Clinically significant cognitive impairment is present in more than a quarter of middle-aged adults who had been diagnosed with type 1 diabetes in childhood, according to a new study.

The results were published online July 7, 2015 in Diabetes Care by Karen A Nunley, PhD, a postdoctoral associate in epidemiology at the University of Pittsburgh, Pennsylvania, and colleagues.

Wide neuropsychiatric testing among 97 adults with an average age of 49 years who had been diagnosed with type 1 diabetes in childhood revealed a prevalence of 28% of clinically significant cognitive impairment, which is comparable to the prevalence of mild cognitive impairment typically reported in adults aged 85 years and older.

The finding raises several concerns, Dr. Nunley told Medscape Medical News.

"We are studying adults who were diagnosed mainly in children, whereas previous studies included individuals diagnosed in adulthood, people who were not exposed to metabolic dysregulation associated with diabetes during critical periods of brain development that occurs during the childhood. "

And, he said, the issues are also middle aged adults "who are at risk of changes" normal "age-related cognitive, the effects of which may be amplified by long-term exposure to diabetes."

One explanation could be that chronic hyperglycemia has negative effects on the cerebral vasculature, similar to that known to occur in the retina or the kidney, he said.

And one of the main concerns is that cognitive impairment can affect a patient's ability to manage their own diabetes. The Poor executive function could hinder time management, the ability to plan and organize, remember details, and to change the approach, Dr. Nunley said, also adding that impaired psychomotor speed may affect the patient's ability to respond quickly to a dangerous situation - for example, while driving.

However, she also stressed that "we are in no way implying that those with onset type 1 diabetes in children can not become successful adults with significant careers. What we hope to do is raise awareness that cognitive impairment It is a possible complication of diabetes, along the lines of retinopathy and neuropathy, so medical providers can help people with type 1 diabetes and their caregivers understand why this happens. "

juvenile DM

Symptoms of DM 1

Friday, 19 June 2015

Do You Support Maggi????

Today everybody in the world especially in India are talking about banning of Nestle Maggi and withdrawn of crores of Maggi stock from the market.

      As we know that till 2 decades Maggi became a part of our life. From 2 years children to 60 years old people eating Maggi as their daily food. It is very difficult to withdraw Maggi from the society because people are addicted to it.

Some reasons why people loving Maggi:
1. It is easy to cook.
2. It is tasty
3. Easy to digest
4. As children does not eat vegetables mothers make them to eat vegetables through Maggie.
5. Some body think it is healthy.
6. It is cheaper when compare to other food.

Government voice towards Maggi:
1. Maggie contains more lead than threshold value.
2. Long term consumption of Maggi leads to lead poisoning called as Lead palsy.
3. The symptoms of lead palsy are brain degeneration, body growth restriction etc.,

Facts about banning of Maggi :
1. it might be the government plan to withdraw Maggi from the market to counter the foreign economy. Because Maggie making more marketing in India.
2. Some body telling that it is plan of Maggie against companies.
3. If Maggi contains lead more than threshold value then why we don't find even one case because of lead poisoning.
4. It is very difficult to withdraw any product from the market when the market is at high range.
5. If maggi noodles contains lead what about other noodles. They are also using almost same formula as maggi noodles.

Alternative steps to decrease lead poisoning instead of banning Maggi:
1. All are telling that it is dangerous to children health then it is suggested that the label content of Maggi will be changed to NOT FOR CHILDREN and they should mention age group on label.
2. The effects of the packed content should be printed on label as we seen in case of tablets. Then the people who want to eat they can eat and who don't want avoid it.
3. Parents don't cook Maggie for children below 12 years to avoid lead poisoning.
4. The final important thing is that government has to take steps for research on Maggie poisoning to prove its harmful contents. Then it will be helpful for public and its employees.

Sunday, 26 April 2015

Race for Pharmaceuticals Store Keeper (total 13 seats) throughout India Institute of Medical Sciences

All India Institute of Medical Sciences was established as an institution of national importance by an Act of Parliament with the objects to develop patterns of teaching in undergraduate and postgraduate medical education in all its branches to demonstrate a high level of medical education in India ; gather in one place educational facilities of the highest order for the training of personnel in all important branches of health activity; and achieve self-sufficiency in Graduate Medical Education.

Post: Store Keeper, Pharmacist

You are invited in the form prescribed by the online mode to fill various Group "A" (No School), Group 'B' and group messaging "C" at AIIMS, New Delhi as in: -
(For details, applicants are encouraged to visit www. and read the instructions carefully before completing this form

Store Keeper (Drugs)
No.of post: 03- UR
Group: B
Pay & pay grade Band: PB-2 Rs.9300-34800 + Grade Pay Rs.4200
Upper age limit: 25 years
Essential eligibility criteria:
(A) essential:
Degree in Pharmacy from the University Desirable recognized / Institution: -
Experience in the storage and distribution of medicines in the pharmacy of a hospital or a well established pharmaceutical concern.
(B) essential:
(I) for Diploma in Pharmacy / Boards recognized institution;
(Ii) three years in a hospital pharmacy or a well established pharmaceutical concern.

Pharmaceutical Grade-II
No.of post 10 (UR-04, ST-02, OBC-04) [01-intended PH (OL, BL)]
Group: C
Pay & pay grade Band: PB-1 Rs.5200-20200 + Grade Pay Rs.2800)
Upper age limit: 30 years
Essential eligibility criteria:
(I) Degree in Pharmacy from the Institution / Board recognized
(Ii) In the case of a pharmacist registered under the Pharmacy Act, 1948
(I) Degree in Pharmacy from the institution / university recognized
(Ii) Experience in the supply and / or storage and dispensing of medicines in a hospital or institution or a reputable pharmacy or a pharmaceutical concern.

Online registration application is available at AIIMS web site from 04/25/2015 to 24/05/2015 9:00 a.m. to 17:00

India Institute of Medical Sciences
ANSARI Nagar, New Delhi-110029


To apply go below link. If the link does not open copy and paste below link in the search box and apply.

Saturday, 11 April 2015

Be Alert of Sun Stroke

Sun Stroke:
        It is defined as the stroke of heart brought about by excessive heat of sun. It is very common in tropical areas like India at summer season. This is common at summer season i.e,. April to June. This condition may be mild to severe. Some times it is fatal especially for pediatrics and geriatrics.

         So, every one should have knowledge about sun stroke to get rid of its fatal effects. Here I am trying to give little idea about symptoms, causes and first aid of sun stroke.

Causes of Sun stroke:
1. Over working in sun heat (especially between 12 Pm to 4 Pm)
2. Fasting in summer seasons.
3. Lack of water drinking

Symptoms of sun stroke:
1. Over thirsty.
2. Giddiness and fatigue.
3. Palpitation.
4. Dry mouth and dry lips.
5. Fever and diarrhea.
6. Hypotension.

Effects of sun stroke:
1. The common effects are weakness.
2. Some times the effects are fatal like excessive diarrhea.
3. Sudden heart stoke.

How to detect Sun stroke:
If any of the above symptoms were seen in patient we decided that it is sun stroke. The patient looses electrolytes due to sun heat so the blood pressure decreases it may leads to decreasing of blood supply to heart which results heart stroke.

First aid for sun stroke:
1. Patient has brought to cool place immediately.
2. Loosen the body clothes to encourage breathing.
3. Give plenty of water.
4. If possible give ORS.
5. If symptoms are severe take patient to hospital immediately.


Prevention measures:
1. Drink plenty of water.
2. Use umbrellas and caps while going to out side in between 12 Pm to 4 Pm.
3. Take fruit juices, coconut water and fruit juices.
4. Wear cotton clothes.
5. Take rest.

Use Umbrella

Drinking water

Cotton fabrics 

Add caption

Sunday, 5 April 2015

Tips to protect health of Aged parents.

Parents are the origin of our lives. All of us know that without our parents we are nothing. So the medical care given to them at old age is the real gift to them by us. So we have to take care of their health. But many of us do not know how to protect their health. Here are some tips to save their health. They are;

 1. Medical care:
Sure that your parents having appointments of medical care. Make sure that your parents receiving proper medical care.

2. Medication safety:
Medication safety is the main part of parents health. So make sure that the medication using by person for any disorder is safe or not.

3. Physical activity:
We have to encourage our parents to do physical activity at the level best depending on their age.

4. Mental health:
Observe their mental health like anxiety and depression. If any signs of mental disorder are observed then immediately get proper therapy.

5. Good nutrition:
Encourage our parents to take healthy and nutrients rich diet to avoid more health problems.

6. Home improvements.
7. Safety-proofing.
8. Helpful devices.
Medical care 

Wednesday, 1 April 2015

Employment opportunity for B.Pharm cool, M.Pharm Clinical Research Associate: SCRI | 5 Opening

The SCRI is an education of a single year and mentoring program for hematology trainees and secondary school teachers in academic medical centers and provides extensive education about clinical research methods, research collaborations, statistical analysis, and management the demands of family and career.
The aim of Saicrinstitute is to produce a group of researchers armed with ideas for hematology and clinical research tools and access to resources for their ideas into reality.

Message: Clinical Research Associate
No.of Since: 05

Job Description
Responsible for management of designated clinical trials including investigator selection, analysis of potential patient recruitment, preparation of documentation related to the trial (protocols, case report forms, brochures researchers, consent documents, letters of agreement, confidentiality agreements), organizing presentations Ethics committee with follow through to ensure successful outcome.

Required Skills: Pharma, Biotechnology, Microbiology

Candidate profile: MPharm, BPharm, BHMS, BNYS, MBB, (biotechnology), (Biotechnology), etc.

Additional Information:
Exprience: 0-1 years
Rating: MPharm, BPharm, BHMS, BNYS, MBB, (biotechnology), (Biotechnology)
Location: Chennai / Bangalore
Industry Type: Pharma, Biotech, clinical data analyst, CRA
Last Date: April 30, 2015


Posted By,
Jagadish M
Sai Institute of Clinical Research

Friday, 20 March 2015

Banasthali Vidhyapith requires Faculty Positions Department of Pharmacy, Pharmacy, Pharmaceutical Chemistry

Banasthali Vidhyapith requires Faculty Positions Department of Pharmacy, Pharmacy, Pharmaceutical Chemistry
The origin of Banasthali is unique in more ways than one. Banasthali owes its existence nor the zeal of a teacher, nor that of a social reformer. Nor is the creation of a philanthropist bag. It has emerged as the fabled phoenix from the ashes of a flower Shanta Bai had withered before flowering. Is a spontaneous filling the void caused by Shantabai was death.It of 6 October 1935 when Smt. Ratan Shastri and Pandit Hiralal Shastri founded Banasthali to fill the void caused by the sudden death of his very talented and promising Shantabai daughter. They had high expectations that would work for the cause of women when she grew up. Love, eternal love has been the source of all thought and action, and this spirit has been the motivating force.

Message: Professor, Associate Professor, Assistant Professor, Research Associate
Science and Technology

Pharmacy, Pharmacy, Pharmaceutical Chemistry

Qualifications as per UGC / AICTE / NCTE / PCI / Bar Council of India norms and Wages in pay bands as Sixth Pay Commission recommendations. Compensation not a hurdle for competent candidates. Reservations for rules Banasthali Vidyapith. Workers must become habitual user of Khadi on appointment.
Applications duly supported by testimonials and portfolio along with recent research publication with a passport size photograph should arrive within three weeks to the Secretary, Banasthali Vidyapith, Banasthali Vidyapith PO-304022 (Rajasthan).

Candidates can download the prescribed application form on the website of the University.

Last Date: April 6, 2015

To download the application please click the link below. If you did not open copy and paste the link into your search box.

Monday, 16 March 2015

Zoledronic acid

     Zoledronic acid is the drug used to treat Osteoporosis and other bone disorders especially for women. It is having several side effects like Osteonecrosis of the jaw.

     Recently, European union advisory board has recommended measures to minimize osteonecrosis of the jaw. Pharmacovigilance Risk assessment committee(PRAC) of Europe has advised that the patients has to remind about adverse effects of Zoledronic acid and patients has to provide leaflets about side effects of drug.

       PRAC also advised that patients has to provide leaflets which contain advantages of treatment with Zoledronic acid and disadvantages of treatment as osteonecrosis of jaw. It is very common side effect in menopause woman than men.

Osteonecrosis of Jaw

Thursday, 12 March 2015

Since the quality Executive Control-, INCHARGE in Tuscany International | can only request candidates with experience

TOSC International Pvt Ltd. is one of the leading pharmaceutical companies in India, since 1985. With two manufacturing units - Delhi and Free Zone excise Pantnagar (Rudrapur), manufacture and supply a wide therapeutic mixture of products in the form of tablets, ointments, syrups, capsules Nutraceuicals (foodstuffs), injections, eye / ear drops. The company has made progress steadily success by earning a prestigious name among pharmaceutical companies in India.

Message: Executive-2 Control of Quality, Quality Control INCHARGE-1

Job Description

Must have good knowledge of instrumental, chemical and microbiological analysis, QA / QC, WHO GMP, documentation, validation, etc.

Instrumental and Microbiology FDA Applicants who are approved in Chemistry section shall be preferred.

Additional Information:
Experience: 10 years
Rating: B.Sc/M.Sc/B.Pharm/M.Pharm
Location: Delhi
Industry Type: Pharma
Functional Area: Quality Control, Pharmaceutical Analysis
Last DATE: 02/28/2015

Where to send your CV in

Please Dont apply fresh candidates

Wednesday, 11 March 2015

Opportunity for Fresh Drug Safety Associate - Pharmacovigilance in HySynth BioTechnologies | 30 Posts

HySynth BioTechnologies is a contract research organization based in Chennai, South India. We Provide outsourced development services on a global basis to the pharmaceutical, biotechnology and medical device industries.

Post: Drug Safety Associate - Pharmacovigilance
No.of post: 30

Job Description
Technicalities in case processing Pharmacovigilance Including case triage, Causality determination coding principles.
• Performed medical coding using MedDRA, Case Narrative writing, submission criteria and regulatory timeline etc. Requirements
• Competent in handling and processing Responsibilities of reviewing adverse events Reported by Investigators and can perform the tasks of conducting research and analyzing medical and scientific literature required at times.
• Proficient in computer Prioritizing tasks and completing computer in Accurately, and Efficiently, yet flexible to multitask When Necessary to Achieve Personal and team goals
Candidate Profile
Life Science, for medical, medical
Ability to work within a team environment
Good interpersonal skills

Additional Information:
Experience: Fresher
Location: Chennai
Fucntional Area: Pharmacovigilance
Industry: Pharma / Biotech
Last Date: 31st March, 2015

Posted By,
Anil Chennupati
Hysynth Bio Technologies
Interested candidates send updated résumés at

Monday, 9 March 2015

Central Council for Research in Siddha invites B.Pharm, M.Pharm Assistant Research Officer, Research Assistant, Pharmacist, Lab Technician, Lab Assistant

        The Central Council for Research in Siddha, a dependent of the Ministry of AYUSH autonomous agency, invites applications from suitable candidates for the following positions of group B and C to be filled by Direct Recruitment. We advise candidates to read the instructions available on the Council website before completing the application. The upper age limit, qualifications and / or experience will be counted as 01/01/2015.

Message: Research Assistant, Research Assistant, Pharmacist, Lab Technician, Lab Assistant

Advertisement No. 02/2015

Research Assistant (Botany / Pharmacognosy)
Pay Scale: (PB2) Rs 9300-34800 + GP Rs.4600
Number of Vacancies: 4 (UR -4)
Age: 35 years and below
Education and other qualifications: Essential: (a) Post-graduate degree in Botany / Pharmacognosy, University / Institution (b) three years of experience in research / teaching recognized in Botany / Pharmacognosy after obtaining Degree (10 + 2 + 3 patterns) in a Ph.D recognized Institution / College / University (OR) in Botany / Pharmacognosy, University / recognized institution.

Research Assistant (Chemistry)
Pay Scale: (PB2) Rs 9300-34800 + GP Rs.4600
Number of vacancies: 2 (UR-2)
Age: 35 years and below
Education and other qualifications: Essential: (a) Post-graduate in Chemistry for / Institution (b) three years of research experience / education recognized University of Chemical after obtaining Degree (10 + 2 + 3 pattern) a recognized Institution / College / University (OR) PhD in Chemistry from the University / Institution recognized.

Research Assistant (Botany)
Pay Scale: (PB2) Rs 9300-34800 + GP Rs.4200
Number of Vacancies: 4 (UR -4)
Age: 30 years and below
Educational and other qualifications: Essential: a) Degree (10 + 2 + 3 pattern) in Botany from the University / Institution recognized. b) Two years of research experience / education in Botany after obtaining the degree (10 + 2 + 3 pattern) in an institution / college / recognized university. (OR) Degree in Botany from the University / Institution recognized

Research Assistant (Chemistry)
Pay Scale: (PB2) Rs 9300-34800 + GP Rs.4200
Number of Vacancies: 4 (UR -3, SC-1)
Age: 30 years and below
Education and other qualifications: Essential: a) Degree (10 + 2 + 3 pattern) in Chemistry from a recognized University / Institution b) Two years experience of research / teaching chemistry after obtaining the degree (10 + Wizard Research (Pharmacology)
Pay Scale: (PB2) Rs 9300-34800 + GP Rs.4200
Number of Vacancies: 1 (UR-1)
Age: 30 years and below
Educational and other qualifications: Essential: BVSc / B.Pharm / M.Sc in pharmacology Assay / Drug college / recognized institution.

Advertisement No. 03/20152 + 3 patterns) in a / College / University recognized institution (OR) Degree in Chemistry from the University / Institution recognized

Advertisement No. 03/2015

Pay Scale: (PB1) Rs 5200-20200 + GP Rs.2800
Number of vacancies: 2 (UR-1, OBC-1)
Age: 25 years and under
Education and other qualifications: Essential: (a) Matric or equivalent (b) Certificate / Diploma in Pharmacy Siddha minimum of two years from a statutory Board / University / Institution (c) recognized two years experience preferably in the clinic / Hospital Medicine Siddha or a recognized pharmacy.

Lab Technician
Pay Scale: (PB1) Rs 5200-20200 + GP Rs.2400
Number of places: 11 (UR -7, SC-2, ST-2)
Age: 25 years and under
Educational and other qualifications: Essential: (a) Degree (10 + 2 + 3 pattern) in science, in the discipline in question (Chemistry / Biochemistry / MLT / Botany) / B.Pharm degree in pharmacology or a university recognized (b) One year of experience in laboratory technology in a laboratory of a hospital / recognized institution (OR) (a) 12 (10 + 2) Class or equivalent with Science subject from a Board / University (b) Diploma recognized Medical Laboratory Technology minimal yearlong from a recognized University / Institution (c) Two years experience in a laboratory recognized Hospital / Institution.

Laboratory assistant
Pay Scale: (PB1) Rs 5200-20200 + GP Rs.2000
Number of vacancies: 3 (UR -3)
Age: 25 years and under
Education and other qualifications: Essential: (a) 12 (10 + 2) Class or equivalent with Science subject from a Board / University (b) Two years experience in a laboratory recognized hospital / recognized institution (OR) Grade (10 + 2 + 3 pattern) {Sciences (Chemistry / Botany) / BSc in pharmacology or B Pharm)

Candidates will be selected on the basis of the written test followed by an interview. The date for the written / interview test will be displayed on the website of the Council and of the call letter will be mailed speed. The deadline for receipt of application is 60 days from the date of publication of this advertisement in the Employment News.

Instructions and guidance to applicants:

It encourages applicants to carefully read all the instructions before completing their applications.
1. The applicant must be a citizen of India.
2. All applicants must meet the essential requirements and other conditions set forth in the notice. You are advised to make sure before applying to have established essential criteria for various posts. No petition asking for advice regarding eligibility will be entertained.
3. The essential criterion is the minimum prescribed mere possession of the same does not entitle candidates to be called for written / interview test. The competent authority reserves the right to shortlist candidates on the basis of qualifications / year of experience in the subject / other higher criteria. The decision of the Director General, CCRS be final in this regard.
4. The period of experience dictated by a candidate on part time basis, the daily wage, visitors / customers teachers will not be counted when calculating the valid experience.
5. The maximum age limit, qualifications and / or experience will be computed as in 01/01/2015
6. Candidates must have passed the qualifying examination and 01/01/2015. Candidates who have come forward to the qualifying examination but whose results have not been declared by the crucial date are not eligible.
7. Degree / Diploma etc. obtained by candidates from open / Education Universities Distance will not be accepted unless it is accompanied by a certificate to the effect that the course is recognized by the Council for Distance Education in terms of Ministry of Human Resource Development Notification No. 44 published in the Gazette of India dated 04/08/1995 by the relevant period when the candidate has acquired the relevant qualification.
8. Candidates serving in Govt. / Autonomous / statutory bodies should only apply through proper channel and duly submitted application should reach the Central Council for Research in Siddha on or before the closing date. Must submit certificate of "no objection" from his employer at the time of the interview. In case you do not provide it, your application will be immediately rejected.
9. Candidates applying for more than one post must submit separate application for each post, along with application fee request. One envelope should contain a single application form. More than one application in one envelope lead to rejection of all these applications. Similarly, more than one application for the same candidate for the same consideration also leads to the rejection of all applications.
10. The vacancies advertised are provisional and may vary. This is subject to change without notice. If the vacant position is indicated in advertising comes down to any number or even zero, the Council is not obliged to compensate the applicant for any consequential damage / loss.
11. DG, CCRS reserves the right to make any modification, cancellation and changes on this page, in whole or in part without assigning any reason thereof.
12. Any error correction / order regarding this advertisement is generated only at the website. We advise candidates to stay in touch with the website for this purpose. No separate error correction etc. will be published in News Jobs or any other newspaper.
13. Applicants will be fully responsible for the accuracy of the information provided. All information provided by the candidate, if you feel unwell at any stage, will lead to his / her disqualification and / or dismissal from the service at any time and no correspondence will be entertained at all.
14. The letter of invitation to the written / interview if shortlisted candidates will be mailed test speed, so that candidates must attach to your 39 / -R. seal affixed in size 26x11 cm. However, the Council will not be responsible for any postal / span delay at all. The date of the written test / interview will be shown on the website of the Council.
15. Appointment to this position will be subject to medical fitness certificate of candidate issued by the Authority Medical Board / Medical competent before joining the post.
16. The applicant will have to appear for written test / interview, if asked, in his / her own expense.
17. The appointment carries with it the responsibility to serve anywhere in India
Will be admitted 18. No correspondence or personal consultations will continue.
19. Canvassing in any form will be treated as a disqualification for the post.
20. Any dispute regarding this contract shall be subject to courts / tribunals with jurisdiction in Chennai.

Number of vacancies for all positions may vary depending on the need of advice
Full details and application form can be downloaded from the website of the Council. /

Last date: 60 days after publication 
Last Date: May 7, 2015

To apply online:
Click the link below or copy and paste search box and download the application form

Sunday, 8 March 2015

Statins-Contraindicated for type 2 Diabetes


         Statins (or HMG-CoA reductase inhibitors) are a class of drugs used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver, which produces about 70 percent of total cholesterol in the body. High cholesterol levels have been associated with cardiovascular disease (CVD). Statins have been found to prevent cardiovascular disease and mortality in those who are at high risk. The evidence is strong that statins are effective for treating CVD in the early stages of a disease (secondary prevention) and in those at elevated risk but without CVD (primary prevention). Side effects of statins include muscle pain, increased risk of diabetes mellitus and abnormalities in liver enzyme tests. Additionally, they have rare but severe adverse effects, particularly muscle damage.
1. Fluvastatin
2. Rosuvastatin
3. Simvastatin etc.,


Type II D.M:
Type II DM is the disease in which insulin deficiency occurs though insulin production is normal but the uptake of insulin by tissues may disturbs leads to imbalanced blood sugar levels. This disorder will be treated with oral hypoglycemics. 
Diabetes Mellitus

Statins are contraindicated for Type II DM patients:
Recent studies telling that usage of statins (HMG-Co A Reductase inhibitors) in CVD patients who have the history of Type II DM may leads to several health disasters as sudden death and sometimes leads to severe heart diseases. So while using statins in Type II DM must be conscious about cardiac diseases.We have to strictly monitor the cardiac markers and all other biological markers to avoid severe heart conditions which are sometimes fatal.

Wednesday, 25 February 2015

New hidden features of IOS 8

Our collection of hidden and undocumented features found in iOS 8, which was released on September 17 See our iOS 8 Summary of official functions.

Credit Card Scanning Safari
Using the stack App
Wi-Fi Calling
Camera Mode Time-Lapse
Hide Pictures in Photos App

If our greatest asset in August raid IOS focuses on major changes announced by Apple, this iOS 8 raid highlights some of the most interesting new features and improvements, but less mobile operating system from Apple around the beta testing period.

Apple released iOS 8 to the public on September 17, 2014, two days before the launch of iPhone 6 and 6 Plus. Before the public launch, the software went through five betas to developers before a master of gold was released on September 9.

The current version of iOS 8 is iOS 8.1.3, a minor update released on January 27 with several bug fixes and performance improvements. Before iOS 8.1.3, Apple released iOS 8.1 with new features like SMS payment Apple and transfer calls. Apple has seeded iOS 8.2 beta for multiple developers, the SDK WatchKit and some other bug fixes. iOS 8.2 could be released in March. iOS 8.3, which adds features like wireless CarPlay and a new emoji selector is also in development.

Tuesday, 24 February 2015

Panobinostat - Get Approval by FDA for the treatment of Relapsed Multiple Myeloma

        The US FDA recently gave approval for Panobinostat for the treatment of Relapsed Multiple Myeloma. Previously in 2014 it was rejected by FDA Oncologic Drugs Advisory Committee  due to its adverse effects. After rejection the manufacturers again submitted additional information to FDA about drug.

      By studying all the information FDA approves Panobinostat.  It is approved to use along with bortezomib and dexamethasone. It is effective in the treatment of Relapsed multiple myeloma in patients who received bortezomab for past 2 years. It is the new class of agents that acts as histone deacetylase inhibitor.

Mechanism of Action of Panobinostat

       It is having new mechanism of action than other cancer agents as histone deacetylase inhibition makes this drug attractive among other cancer drugs. The safety and efficacy data of Panobinostat is based on the clinical study on 193 patients who had received prior treatment with bortezomib and immuno modulatory agents. The clinical phase used is phase 3, randomized,double blind,placebo controlled, multicenter global registration trail. This drug is having several adverse effects which make it rejection by FDA previously.

Adverse effects:
The common adverse effects are,
1. Nausea
2. Vomiting
3. Diarrhoea and
4. Fatigue.

        The most common side effects of this drug in clinical trails are diarrhea, fatigue, nausea, peripheral edema, decreased appetite, pyrexia, and vomiting, with the most common nonhematologic laboratory abnormalities.

Panobinostat capsules

         Common hematologic abnormalities include thrombocytopenia, lymphopenia, leukopenia,neutropenia and anemia. The serious side effect include cardiac toxicity and severe diarrhoea.

So, the patients who receiving panobinostat had to monitor for the adverse effects especially for anemia.

Sunday, 15 February 2015

Ovarian cancer risk may increased by Hormone Replacement Therapy

           At menopause stage the women bodies stop producing sex hormones (estrogen,progesterone) which are important to maintain normal physiological functions like metabolism,mental activities etc., So after menopause (at post menopausal stage) woman starts to take Estrogen and progesterone pills under the super vision of gynecologist. This is called as Hormone Replacement Therapy (HRT) .

     HRT therapy having some side effects. These are common and mild in nature like dizziness,weight gain,mood swings etc., Recent studies reveal that long term use of HRT may increase the risk of ovarian cancer. The researchers conducted epidemiological studies at U.S by using case and control group and concluded that HRT may increases cancer risk.

            It is very severe in the patients in whom ovaries are dissected at the time of hysterectomy. But risk is lesser in patients with ovaries. The researchers conduct case control study in which, group is Patients are post menopausal and having ovarian cancer
2. Control group is patients are postmenopausal but not having ovarian cancer and still having their ovaries.

            They compare both groups by conducting meta-analysis and concluded that the usage of HRT for even less period may increases the cancer risk up to 20% . The researchers also told that patient related factors like body weight,hysterectomy, other diseases does not shows effect on HRT. The more the recent the therapy the great the risk. Woman who had stopped HRT recently but were within 5 years of last use at the time of their cancer risk , although having used HRT for at least 5 years was still associated with 10% increased relative risk more than 5 years later.

Ways to avoid Adverse effects of HRT :
There are some ways to relief from the side effects of HRT. If we follow these we can get rid of side effects. They are, 
1. Yoga
2. Aerobics
3. Healthy food
4. Daily exercises
5. Meditation etc.,

HRT Pill


Friday, 6 February 2015

New FDA Clearance for Ranibizumab for Diabetic Retinopathy with DME

     The USFDA has expanded sate use of Ranibizumab for diabetic retinopathy ane Diabetic Macular Edema (DME) treatment. Diabetes is one of the deadly disease that affecting millions of people every year world wide. In this disease the sugar levels of blood will changes time to time with our order. The patient looses body sugars in urine which makes fall down of sugar levels.

    At the time of eating body sugar levels will increases suddenly which damages body organs. Diabetic patients are more prone to organ damages. The main organ is eye. Several diabetic patients are suffering with diabetic retinopathy which impairs vision. So it needs proper treatment. Organ failure chances will increase with age. It is the most common diabetic eye disease and is leading cause of blindness in adults in US.
Diabetic retinopathy

   The present drug Ranibizumab is the first significant therapy to treat diabetic retinopathy and diabetic macular edema.

Safety and Efficacy studies of Ranibizumab:
   This profile is obtained by 2 clinical studies involving 759 participants who were treaed and followed for 3 years. In the two studies, treatment with Ranibizumabled to significant improvement in severity of DME and diabetic retinopathy when compared with the patients who does not receiving the drug.

Side effects:
1. Bleeding of conjuctiva
2. Eye pain
3. Floaters
4. Increased IOP(Intra Occular Pressure)
5. Endophthalmitis and retinal detatchment (Serious)


    Previously FDA had approved ranibizumab to treat DME and macular edema secondary to retinal vein occlusions, both of which cause fluid to leak into the macula result in blurred vision. Recently FDA granted the Ranibizumab for diabetic retinopathy with DME and reviewed this new use for the drug under the agency's priority review program, which provides for an expedited review of drugs. This drug provides safe and effective treatment in serious condition.

Route of administration:
Ranibizumab is administered by IV injection once monthly.

Other uses of Ranibizumab:
It is also approved for the treatment of neovascular (wet) age related macular degeneratin in US.


Wednesday, 21 January 2015


Yes, obviously.....
The recent studies conducted in U.K telling that cancer deaths can be prevented in the age group of below 80 years by the year of 2050. Cancer occurrence at younger stage and adult age below 80 tears can be cured by using present treatment methods.

How can we??
      This is the question that everyone will ask after hearing this news. Here, is the answer. As we know that the main problem in the treatment of cancer is, delay in the detection. Cancer symptoms are not at all detectable at the early stages. In some persons a few symptoms may be detectable. Because the symptoms of cancer are same as other common diseases.

How to detect cancer at early stages:
 To detect cancer at early stages we need some knowledge.
1. Every person has to aware about cancer symptoms.
2. Government and other professionals have to take step forward to educate people about symptoms.
3.  Encourage people to consult physician when suspicious cancer symptoms are detected.

Main cancers that causing more deaths:
There are some cancers in the modern society that causes more deaths. They are
1. Ovarian cancer
2. Breast cancer
3. Prostate cancer
4. Oral cancer
5. Colon cancer
These are some of the main cancer that are causing deaths. So the society has to conscious about the symptoms of these types of cancers.

Illustration Of Ovarian Cancer
Ovarian cancer

Preventive Measures:
        Everyone is thinking that cancer is the deadly disease and if cancer occurs there is no way for anything that death. First we have to erase this belief from minds. Several people scare to consult physician with cancer symptoms by expecting the diagnostic outcome. So, we have to encourage to consulting physician.

It is not easy to prevent cancer without proper steps. Here are some of them.
1. Follow healthy life style.
2. Early detection of disease.
3. Advanced diagnostic techniques
4. Advanced treatment methods
5. Healthy food habits
6. Medication adherence
Healthy food

Sunday, 18 January 2015


     Obesity is one of the major cause of several diseases now a days. The obesity cases are increasing gradually day by day in modern society. A new endocrine Society Clinical-practice guideline on the pharmacological management of obesity outlines a plan for the use of weight loss medications and get away from the medication which are associated with weight gain.

    Professionals who involved in the present research warns the health care professionals that, they must treat the obesity first before going to treat other comorbidities caused by weight gain like,
1. Diabetes
2. Hypertension and
3. Dislipidamia.

Drugs available for the treatment of Obesity:
1. Buprapion/Naltroxone
2. Liraglutide

   These agents join with controlled-release Phentermine, Topiramate and Lorcaserine to treat obesity. Orlistat is available as over the counter drug in the U.S market.

    Use of  approved medication weight-loss medications is used for the people with a BMI of 30 kg/m2 or atleast 27 kg/m2 with or 1 or more comorbidities.

    Pharmacological treatment of obesity is bariatric surgery and usage of approved weight loss medication. But the bariatric surgery involves more complications than medication. Where as
 the weight loss medication usage are convinced by several patients.

Change your food Hbits

   The researchers also telling that the doctors has to treat obesity first and also recommend life style modifications like Yoga, Aerobics etc., Hypoglycemic agents like Metformin and other drugs can increases body weight. So the doctors has to be cautious about this medication.



 If there is no change in weight even after the 2 weeks of therapy with any weight loss medication then immediately stop that agent and skip for other medication.

Friday, 16 January 2015

NSAIDs protects from skin cancer

What are NSAIDs:
Non Steroidal anti Inflammatory Drugs are the agents which are having 3 types of activities
a. Anti pyretic
b. Anti inflammatory and
c. Anti analgesic activity

Non aspirin NSAIDs (Ibuprofen)

Aspirin tablets

Significance of NSAIDs:
1. Used for body aches
2. Used for hyperthermia (Fever)
3. At inflammatory conditions
4. NSAIDs are the choice of drug for arthritis and gout.

Side effects of NSAIDs:
1. Hepatic failure at higher doses for a longer period of time
2. Gastric irritation, gastric bleeding

Contraindications of NSAIDs:
1. NSAIDs are contraindicated for renal impaired patients because NSAIDs are excreted through renal route.
2. NSAIDs are contraindicated for hepatic impaired patients because it is metabolized by glucuronidyl pathway of liver.
3. Contraindicated for gastritis patient as NSAIDs causes gastric bleeding.

Recently it is proved that usage of NSAIDs may protect from skin cancer.
It is already proven that the persons who are using NSAIDs for various health disorders are protective against several cancers like,
1. Prostate cancer
2. Colon cancer
3. Breast cancer and
4. Lung cancer

Now it is evident that NSAIDs also protects from Squamous Cell Carcinoma (SCC), one type of skin cancer. NSAIDs like Aspirin and Non Aspirin usage protects from SSC AND other cancers. 

Mechanism by which NSAIDs protects from SSC:
NSAIDs inhibits Cyclooxigenase (COX-2) enzyme and inhibits prostaglandins (PG's) which are the mediators of inflammation. So, they inhibit the formation of tumors. By this they protects from SCC. But NSAIDs will not protective against all types of cancers but can protect from some types of tumors as we discuss above. 


        This is the new research that counters the earlier evidences which told that usage of mobile and cordless phones causes cancer. Several researchers told that cell phone usage causes health disorders like skin cancers, brain tumors.
      One research that conducted in U.S told that it causes "Gliomas", type of brain tumor. To counteract this one other group of researchers starts study on people who are frequently using mobiles. It is not easy to conduct Randomized control trail. Because RCT needs to follow group of patients to a certain period of time and also it needs large test population.
        It is also very expensive to conduct. So they conduct case control and cohort study on 1,00,000 people over 10 years. They conduct study in 5 countries all over the world. They observe that the incidence of cancer is only to small extent i.e., 9 in 10,000 people. It is not that much severe condition. So, researchers telling that cell phone usage do not cause brain tumors.
But we have to mind that the radiation releases from mobiles and cordless phones are very dangerous. They can affect health of pregnant women. They also dangerous to children aged below 10 years.
Effects of radiation:
1. It affects pregnant health condition.
2. Affects children health especially brains.
3. Affects bird’s health.
4. May causes some types of skin cancers.
        So, we have to cautious about mobile usage. Especially pregnant women must use head phones while talking in mobiles. Parents never allow children(less than 10 years) to use mobiles more than 1 hour. Every one should use radition free mobiles to save ourselves from radiation. 

Radiation is dangerous for children

Steps to follow to protect ourselves from radiation:
1. Never sleep with mobile under your pillow. Keep mobile at least 10-20 meters away from head.
2. Always use left ear for mobile talking.
3. Never talk by mobile at the time of mobile charging.
4. Never talk by mobile when it is having low battery level (below 10%). At that time the radiation is 1000 times more than normal.
5. Never keep mobile near to vital organs like breast (especially female), heart, testis etc.,

Mobile radiation

Note: Check your mobile radiation by dialing *#07#. If it is less than 1.6 watt/kg its fine but if it is not showing any thing after dialing *#07# then immediately change your mobile as it is having more radiation that is why it is not showing any thing.

Wednesday, 14 January 2015


Anti Microbial Resistance (AMR):
    This is the condition in which the microbe shows resistance to the respected antibiotics. It mean that the microbe will not killed by antibiotic. This is also called as antibiotic failure.
Eg: Multi Drug Resistance by bacteria Mycobacterium Tuberculae.
      Antibiotic resistance is the alarming future disaster in all over the world. Antibiotic is one of the chemical compounds that are developed to counteract bacteria, virus and all other microbes.
     They counteract microbes and kill them to protect body. Now a day’s means past from 20 years microbial infections occupies major part in disease conditions. Simultaneously antibiotic use also increases. Physicians are prescribing more antibiotics even for small diseases. Some physicians are prescribing strong antibiotics. So the antibiotic resistance is developing in the present society drastically.
     Once one microbe will develops resistance it never be killed by any antibiotic. So physicians should mind about this while prescribing antibiotics. Any treatment for infections by antibiotics must start with weak antibiotics. If that antibiotic dies not show action one should go for another antibiotic. But never use strong antibiotic initially. Antibiotic prescription needs evidence of culture sensitivity test. Prescribing antibiotic without culture test is not a rational prescribing.

      Researchers and professionals telling that antibiotic resistance will be the upcoming future disaster that the world should face.  It is the severe disaster than all other diseases. So, we have to search ways to avoid this.
Till today 7,00,000 people are suffering from AMR (Anti Microbial Resistance).
By the year 2050 it may be 10 million.

Several diseases are there that developing resistance to antibiotics. Some of them are,

  1.  Cholera
  2.  Tuberculosis
  3.   Diarrhoea
  4.  Measles
  5. Tetanus etc.,

Reasons for the development of AMR:

The reasons may be;
  1. Using antibiotics without prescription.
  2. Prescribing antibiotics without proper evidence.
  3. Prescribing strong antibiotics to small infections.
Steps to follow to avoid AMR:
  1.  Should conduct culture sensitivity tests before going to prescribe antibiotics.
  2.  Never use antibiotics without prescription.
  3. Culture sensitivity test
  4. Prescribe weak antibiotics initially.